Level 2 – Module 22019-02-19T13:34:35+00:00

LEVEL II – Expert course

Module 2

Aetiology of autism and comorbid conditions

a) Epidemiology of autism spectrum disorder.

b) Risk factors.

c) Autism genetics.

d) Neurobiological basis of autism.

e) Autism and comorbidities.

  1. Understand and explain changing epidemiology of autism spectrum disorder.
  2. Understand a complex interplay between genetic and environmental risk factors.
  3. Know main genetic and neurobiological explanatory models of autism spectrum disorder.
  4. Describe and interpret the most frequent comorbid conditions associated with autism.
  • Chen, B. C. et al. Treatment of Lesch–Nyhan disease with S adenosylmethionine: experience with five young Malaysians, including a girl. Brain Dev. 36, 593–600 (2014).
  • Curatolo, P., et al. (2004). Autism in tuberous sclerosis. Eur J PaediatrNeurol 8:327-332.
  • DSM-5 criteria
  • Glick, N. Dramatic reduction in self-injury in Lesch–Nyhan disease following S adenosylmethionine administration. J. Inherit. Metab. Dis. 29, 687 (2006).
  • Hagberg B (1995) Rett syndrome: clinical peculiarities and biological mysteries. ActaPaediatr 84:971-976.
  • http://hdl.handle.net/11245/1.532127
  • Koukoui SD, Chaudhuri A (2007) Neuroanatomical, molecular genetics, and behavioral correlates of fragile X syndrome. Brain Res Rev 53:27-38.
  • Lyall, K., et al. (2017). The changing epidemiology of autism spectrum disorders. Annual Review of Public Health, 38, 81-102.
  • Matson, J. L., &Sturmey, P. (Eds.). (2011). International handbook of autism and pervasive developmental disorders. Springer Science & Business Media.
  • Moreno-De Luca, D., et al. (2010). Deletion 17q12 is a recurrent copy number variant that confers high risk of autism and schizophrenia. Am. J. Hum. Genet. 87, 618–630.
  • Moreno-De Luca, D. et al. (2012). Using large clinical data sets to infer pathogenicity for rare copy number variants in autism cohorts. Mol. Psychiatry 18, 1090–1095.
  • Parellada, M., et al. (2014). The neurobiology of autism spectrum disorders. European Psychiatry, 29(1), 11-19.
  • Phelan, K. & McDermid, H. E. (2012). The 22q13.3 deletion syndrome (Phelan–McDermid syndrome). Mol. Syndromol. 2, 186–201.
  • Radoeva, P.D., et al. (2014). Association between autism spectrum disorder in individuals with velocardiofacial (22q11.2 deletion) syndrome and PRODH and COMT genotypes. Psychiatr Genet 24:269-272.
  • Veltman, M.W., et al. (2005). Autism spectrum disorders in Prader-Willi and Angelman syndromes: a systematic review. Psychiatr Genet 15: 243-254.
  • Vorstman, J. A., et al. (2017). Autism genetics: opportunities and challenges for clinical translation. Nature Reviews Genetics.
  • Woodman, A. C., et al. (2016). Trajectories of internalizing and externalizing symptoms among adults with autism spectrum disorders. Development and Psychopathology, 28(2), 565-581.
  • https://ec.europa.eu/health/major_chronic_diseases/diseases/autistic_en#fragment1
  • https://ec.europa.eu/health/sites/health/files/major_chronic_diseases/docs/asds_eu_en.pdf

The trainee should complete four theoretical-practical activities and then complete a self-evaluation questionnaire consisting of 20 questions.

It is considered that the trainee was successfully completed the module if he realized all the activities envisaged and gave at least 75% of the correct answers on the evaluation test.

Self assessment questionnaire