Nivel 2 – Módulo 22019-02-19T12:25:10+00:00

Nível II – Curso Avançado

Módulo 2

Etiologia do autismo e comorbilidades

a) Epidemiologia do autismo.

b) Fatores de risco.

c) Genética do autismo.

d) Base neurobiológica do autismo.

e) Autismo e comorbilidades.

  • Compreender e explicar a mudança da epidemiologia no autismo.
  • Compreender a interação complexa entre os fatores de risco genéticos e ambientais.
  • Conhecer os principais modelos explicativos, genéticos e neurobiológicos no autismo.
  • Chen, B. C. et al. Treatment of Lesch–Nyhan disease with S adenosylmethionine: experience with five young Malaysians, including a girl. Brain Dev. 36, 593–600 (2014).
  • Curatolo, P., et al. (2004). Autism in tuberous sclerosis. Eur J Paediatr Neurol 8:327-332.
  • DSM-5 criteria
  • Glick, N. Dramatic reduction in self-injury in Lesch–Nyhan disease following S adenosylmethionine administration. J. Inherit. Metab. Dis. 29, 687 (2006).
  • Hagberg B (1995) Rett syndrome: clinical peculiarities and biological mysteries. ActaPaediatr 84:971-976.
  • http://hdl.handle.net/11245/1.532127
  • Koukoui SD, Chaudhuri A (2007) Neuroanatomical, molecular genetics, and behavioral correlates of fragile X syndrome. Brain Res Rev 53:27-38.
  • Lyall, K., et al. (2017). The changing epidemiology of autism spectrum disorders. Annual Review of Public Health, 38, 81-102.
  • Matson, J. L., &Sturmey, P. (Eds.). (2011). International handbook of autism and pervasive developmental disorders. Springer Science & Business Media.
  • Moreno-De Luca, D., et al. (2010). Deletion 17q12 is a recurrent copy number variant that confers high risk of autism and schizophrenia. Am. J. Hum. Genet. 87, 618–630.
  • Moreno-De Luca, D. et al. (2012). Using large clinical data sets to infer pathogenicity for rare copy number variants in autism cohorts. Mol. Psychiatry 18, 1090–1095.
  • Parellada, M., et al. (2014). The neurobiology of autism spectrum disorders. European Psychiatry, 29(1), 11-19.
  • Phelan, K. & McDermid, H. E. (2012). The 22q13.3 deletion syndrome (Phelan–McDermid syndrome). Mol. Syndromol. 2, 186–201.
  • Radoeva, P.D., et al. (2014). Association between autism spectrum disorder in individuals with velocardiofacial (22q11.2 deletion) syndrome and PRODH and COMT genotypes. Psychiatr Genet 24: 269-272.
  • Veltman, M.W., et al. (2005). Autism spectrum disorders in Prader-Willi and Angelman syndromes: a systematic review. Psychiatr Genet 15: 243-254.
  • Vorstman, J. A., et al. (2017). Autism genetics: opportunities and challenges for clinical translation. Nature Reviews Genetics.
  • Woodman, A. C., et al. (2016). Trajectories of internalizing and externalizing symptoms among adults with autism spectrum disorders. Development and Psychopathology, 28(2), 565-581.
  • https://ec.europa.eu/health/major_chronic_diseases/diseases/autistic_en#fragment1
  • https://ec.europa.eu/health/sites/health/files/major_chronic_diseases/docs/asds_eu_en.pdf

Os formandos têm que realizar 2 atividades teórico-práticas e um questionário de avaliação composto por 20 questões.

Para os formandos completarem o módulo com sucesso e serem considerados aprovados, deverão realizar todas as atividades previstas no guia de atividades e responder corretamente a pelo menos 75% das questões do questionário de avaliação.

Questionário de Avaliação